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KMID : 0982820060050010047
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Journal of Lung Cancer
2006 Volume.5 No. 1 p.47 ~ p.50
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A Case of Pulmonary Thromboembolism Developed during Chemotherapy with Gemcitabine and Cisplatin for Non- small Cell Lung Cancer
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Kim Kyu-Sik
Oh In-Jae
Kim Soo-Ock
Son Jun-Gwang
Jeong Jong-Pil
Kim Yu-Il
Lim Sung-Chul
Kim Young-Chul
Chung Jong-Won
Park Kyung-Ok
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Abstract
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Lung cancer patients have increased risk of thromboembolism (TE) due to various factors such as by hypercoagulability, tumor thrombosis, decrease of ambulation, and chemotherapy etc. Among these factors, chemotherapy associated TEs have been reported, although the causes and pathomechanisms of TEs were not clear. Recently, reports proposed the potential role of platelets in endothelial damage by the chemotherapeutic agents. We have experienced a case of pulmonary TE after systemic chemotherapy with gemcitabine and cisplatin. The patient complained aggravated exertional dyspnea after chemotherapy and diagnosed as pulmonary TE by computerized tomogram. After anticoagulation and interruption of the chemotherapy, improvement of exertional dyspnea and resolution of the pulmonary TE were observed.
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KEYWORD
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Gemcitabine, Thromboembolism, Lung cancer
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